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Pesticides >> Insecticide>> Cyhalothrin


Cyhalothrin 95%TC
Cyhalothrin 25%EC


Common name cyhalothrin (BSI, draft E-ISO, BAN); cyhalothrine ((f) draft F-ISO)
IUPAC name (RS)-a-cyano-3-phenoxybenzyl (Z)-(1RS,3RS)-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate
Roth: (RS)-a-cyano-3-phenoxybenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate
Chemical Abstracts name [1a,3a(Z)]-(?-cyano-(3-phenoxyphenyl)methyl 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate
CAS RN [68085-85-8] Development codes PP563; ICI 146 814 (both ICI) Official codes OMS 2011

Mode of action Non-systemic insecticide with contact and stomach action, and repellent properties. Gives rapid knockdown and long residual activity. Uses Control of animal ectoparasites, especially Boophilus microplus and Haematobia irritans on cattle, and Bovicola ovis, Linognathus spp. and Melophagus ovinus on sheep. Applied as an animal dip or as a spray around animal houses. Formulation types EC; WP. Selected tradenames: 'Cyhalon' (Syngenta); 'Grenade' (Syngenta)

Product analysis of pyrethroids reviewed by E. Papadopoulou-Mourkidou in Comp. Analyt. Profiles. By hplc (A. Jacques et al., Anal. Methods Pestic. Plant Growth Regul., 1984, 13, 9). Residues determined by glc with ECD (idem, ibid.). Details available from Syngenta.

Reviews JECFA 54, FAO/WHO 42, 43 (see part 2 of the Bibliography). Oral Acute oral LD50 for male rats 166, female rats 114, guinea pigs >5000, rabbits >1000 mg/kg. Skin and eye Acute percutaneous LD50 for male rats 1000-2500, female rats 200-2500, rabbits >2500 mg/kg. Moderate eye irritant; not a skin irritant (rabbits). Moderate skin sensitiser (guinea pigs). Inhalation LC50 (4 h) for rats >0.086 mg/l. NOEL No significant toxicological effect observed in feeding trials with rats (2 y) or dogs (0.5 y) at 2.5 mg/kg daily. ADI (JECFA) 0.002 mg/kg b.w. (temporary) [2000]; (JMPR) 0.02 mg/kg b.w. [1984]. Other No evidence of carcinogenicity, mutagenicity or disturbed reproductive functions; no adverse effects on foetal development. A facial sensation may be experienced by users of the chemical; this is transient, with complete recovery. Toxicity class WHO (a.i.) II

Birds Acute oral LD50 for mallard ducks >5000 mg/kg. Fish LC50 (96 h) for rainbow trout 0.00054 mg/l. Daphnia LC50 (48 h) 0.38 mg/l.

EHC 99 (WHO, 1990). Animals In rats, following oral administration, cyhalothrin is rapidly eliminated in urine and faeces. The ester group is hydrolysed, both moieties forming polar conjugates. Soil/Environment In soil, DT50 c. 4-12 weeks. Leaching of cyhalothrin and its degradation products through a range of soil types is negligible.

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